QbD Group
    White Paper

    Sponsor Responsibilities in IVD Clinical Performance Studies

    Understand sponsor responsibilities in IVD clinical performance studies under IVDR, FDA IDE and ISO 20916, including delegation, CRO roles and combined study models.

    关于本白皮书

    本资源涵盖的关键主题

    Performance studies generate the clinical evidence needed to support regulatory approval of in vitro diagnostic devices and companion diagnostics.

    Under both European and U.S. frameworks, the Sponsor carries ultimate responsibility for the scientific validity, ethical conduct and regulatory compliance of the study.

    However, the way sponsorship is structured can significantly influence:

    • regulatory accountability
    • control of clinical evidence
    • operational efficiency
    • data ownership for regulatory submissions

    This white paper clarifies the responsibilities attached to the Sponsor role and provides practical guidance for manufacturers, pharmaceutical partners and CROs involved in IVD performance studies.

    What you'll learn

    Key takeaways from this document

    In this white paper, you'll discover:

    • The regulatory responsibilities of Sponsors under EU IVDR, FDA IDE and ISO 20916
    • Which activities can be delegated to CROs and which responsibilities cannot
    • Key considerations when selecting a CRO for IVD performance studies
    • Different sponsorship models in combined drug–diagnostic studies
    • Practical strategies to ensure compliant and scientifically robust performance studies

    关于作者

    Annelies Rotthier
    Annelies Rotthier

    Expert in IVD clinical trials and regulatory compliance.

    关于作者

    Kirsten Van Garsse
    Kirsten Van Garsse

    MSc Biomedical Sciences · Business Unit Manager RA IVD & Representative Services

    With over 20 years of experience in the diagnostics industry, Kirsten leads the IVD Regulatory Affairs business unit at QbD Group, guiding regulatory strategy and compliance across all IVDs with a focus on companion diagnostics.

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