---
title: "Cleaning Validation Based on PDEs"
description: "Join our webinar and discover how to apply PDEs (Permitted Daily Exposures) to minimize critical risks and ensure regulatory compliance, combining science, statistics, and advanced digital tools. Learn from experts how to transform cleaning validation into a safer, more efficient, and predictable process."
url: https://qbdgroup.com/es/webinars/cleaning-validation-based-on-pdes-on-demand
type: "Webinar"
language: es
published: 2026-03-13
category: "Qualification & Validation"
publisher: "QbD Group"
citation: "QbD Group, \"Cleaning Validation Based on PDEs\", https://qbdgroup.com/es/webinars/cleaning-validation-based-on-pdes-on-demand"
---
# Cleaning Validation Based on PDEs
> Join our webinar and discover how to apply PDEs (Permitted Daily Exposures) to minimize critical risks and ensure regulatory compliance, combining science, statistics, and advanced digital tools. Learn from experts how to transform cleaning validation into a safer, more efficient, and predictable process.

## Avoid Critical Risks and Ensure Compliance at Your Pharmaceutical Plant

Cleaning validation is a critical pillar in pharmaceutical manufacturing, ensuring patient safety and regulatory compliance. PDEs *(Permitted Daily Exposure)* have become the scientific reference for defining safe residual contamination limits, but their correct application requires technical, regulatory, and toxicological understanding.

In this webinar, you will discover **how to integrate PDE-based criteria into your cleaning validation strategies**, with a practical approach that combines regulation, data analysis, and advanced digital tools.

## What you will learn

- How to use PDE as an essential part of cleaning validation through the correct selection of worst case and the establishment of adequate acceptance criteria, allowing you to guarantee the safety of manufactured medicines.
- Key regulatory requirements (EMA, ICH Q3, ICH Q9, PIC/S PI 006-3) and how to comply with them effectively.
- How to calculate PDEs from preclinical and clinical data, including formulas, correction factors, and clarification of frequently asked questions.
- Practical stages of cleaning validation, from design to approval.
- Applications of AI and digitalization for prediction, optimization, and intelligent management of the validation process.

## Speakers

Hear from industry experts who bring practical experience in validations and toxicology.

### Ramiro Murillo
**Qualification & Validation Expert**

![Ramiro Murillo](https://jrtdedcfhvzaomneervp.supabase.co/storage/v1/object/public/webinar-images/speaker-ramiro-murillo.png)

Pharmacist with experience across the entire drug manufacturing chain, with special emphasis on equipment qualification, process validation, and analytical methods. Master in Research, Development and Control of Medicines from UB. Currently serves as Qualification & Validation Expert at QbD Group, developing optimization and cleaning process validation projects in the pharmaceutical industry.

### Elena Isabel Nieves
**Toxicology Expert**

![Elena Nieves](https://jrtdedcfhvzaomneervp.supabase.co/storage/v1/object/public/webinar-images/speaker-elena-nieves.png)

Toxicologist with a solid background in Biotechnology and a double master's degree in Biomedicine and Scientific Department Management, with a PhD in Toxicology from UCM. With previous experience in biomedical research and more than four years in scientific consulting, she has developed a solid track record in preparing PDE/ADE reports and toxicological assessments according to ICH guidelines (Q3D, Q3A/B, M7). Currently a Toxicology Expert in the Toxicology department at QbD Group, leading impurity assessment and toxicological risk management projects for the pharmaceutical industry.

### María José Villarroel
**Toxicology Manager**

![María José Villarroel](https://jrtdedcfhvzaomneervp.supabase.co/storage/v1/object/public/webinar-images/speaker-maria-jose-villarroel.png)

Graduate in Biological Sciences, PhD in ecotoxicology and environmental contamination, holds the European Registered Toxicologist (Eurotox) credential since 2013. She is also the author of 19 scientific publications in JCR journals, and more than 30 communications at congresses related to environmental toxicology and ecotoxicology.

She has more than 20 years of practice in toxicology in both phytosanitary and cosmetic fields. Additionally, she has participated in research projects funded by both public and private entities.
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Source: https://qbdgroup.com/es/webinars/cleaning-validation-based-on-pdes-on-demand — © QbD Group. Quote freely with attribution and a link back.